Side effects of amiodarone include various pulmonary effects. The most serious reaction that is due to amiodarone is interstitial lung disease. Risk factors include high cumulative dose, more than 400 milligrams per day, duration over two months, increased age, and preexisting pulmonary disease. Eye Rounds Atlas. A collection of images and very brief reports. Please click on image for a closer look. Synonym: thyrotoxicosis. See also separate Hyperthyroidism in Pregnancy and Thyroid Eye Disease articles. Hyperthyroidism is overactivity of the thyroid gland, which results in a number of symptoms and signs. The most widely studied of the systemic drugs that produce corneal epithelial changes is amiodarone. Amiodarone is a potassium channel–blocking antiarrhythmic agent developed in Europe in 1961 to treat ventricular fibrillation but was not approved by the FDA until 1985. A 50-year-old woman was referred by her general practitioner after she reported seeing halos around lights through both eyes for a few weeks. She had no history of ocular trauma or previous. Madarosis is a condition that results in the loss of eyelashes, and sometimes eyebrows. The term madarosis is Greek for the word madao which means to fall off. Als Vortexkeratopathie (lat. Cornea verticillata, Cornea = ‚Hornhaut‘) bezeichnet man wirbelartige Ablagerungen im Hornhautepithel der Augen. In den meisten Fällen handelt es sich um eine Nebenwirkung bestimmter Arzneistoffe. Disease Entity. Toxic optic neuropathy (TON) refers to visual impairment due to optic nerve damage caused by a toxin (1). Toxic optic neuropathy is characterized by bilateral, usually symmetric vision loss, papillomacular bundle damage, central or cecocentral scotoma, and reduced color vision. Published November 15, 2002 Antiepileptic Drug And Glaucoma Research has recently described a complication in a new anti-seizure drug. Christopher J. Quinn, O.D. ALERT: U.S. Boxed Warning Life-threatening arrhythmias (tablet): Amiodarone is intended for use only in patients with indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity.